190604-20-7

Basic information

• Product Name: 6-[(4-cyanophenyl)-(E)-ethenyl]-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester
• Synonyms: 6-[(4-cyanophenyl)-(E)-ethenyl]-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester
• CAS NO: 190604-20-7
• Molecular Weight: 388.466
• Mol File: 190604-20-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-[(4-cyanophenyl)-(E)-ethenyl]-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(4-cyanophenyl)-(E)-ethenyl]-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester(190604-20-7)
• EPA Substance Registry System: 6-[(4-cyanophenyl)-(E)-ethenyl]-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester(190604-20-7)

Safety Data

• Hazardous Substances Data: 190604-20-7(Hazardous Substances Data)

Upstream product

• 3435-51-6 4-ethenylbenzonitrile 
• 164147-71-1 (1-Oxo-6-trifluoromethanesulfonyloxy-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester 
• 22245-98-3 6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 164147-66-4 6-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 164147-68-6 6-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester 
• 164147-67-5 (6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester 

Downstream Products

• 1026228-40-9 {6-[(E)-2-(4-Carbamimidoyl-phenyl)-vinyl]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 1026390-53-3 {6-[(E)-2-(4-Methylsulfanylcarbonimidoyl-phenyl)-vinyl]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 190604-21-8 (6-{(E)-2-[4-(tert-Butoxycarbonylamino-imino-methyl)-phenyl]-vinyl}-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester 
• 1027422-55-4 {1-Oxo-6-[(E)-2-(4-thiocarbamoyl-phenyl)-vinyl]-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 

Relevant articles and documents

Non-peptide RGD surrogates which mimic a Gly-Asp β-turn: Potent antagonists of platelet glycoprotein IIb-IIIa

Cyclic heptapeptide 1, which contains an Arg-Gly-Asp sequence, has good affinity for the platelet receptor GPIIb-IIIa and was chosen for study by 1H NMR techniques. The key RGD sequence of this molecule was found to reside in a conformationally defined type II' Gly-Asp β-turn, and this information was used in the design of simple non-peptide RGD mimics. Disubstituted isoquinolones, bearing an acidic side chain at position 2 and a basic side chain at position 6, were prepared and were found to have modest affinity for GPIIb-IIIa. Systematic modification of the basic residue contained in these molecules yielded compounds with high affinity for GPIIb-IIIa.