19061-64-4Relevant academic research and scientific papers
Silicon switch approach in TRPV1 antagonist MK-056 and its analogues
Chang, Minsun,Park, Seol-Rin,Kim, Juhyun,Jang, Mijung,Park, Jeong Hyun,Park, Ji Eun,Park, Hyeung-Geun,Suh, Young-Ger,Jeong, Yeon Su,Park, Young-Ho,Kim, Hee-Doo
experimental part, p. 111 - 116 (2010/03/30)
In searching for opportunities to exploit the benefits of silicon in TRPV1 research, we tried to investigate the pharmacological effects of sila-substitution (C/Si exchange) of tert-butyl group in the MK-056 series. Compound 13a, with a 4-positioned trime
Development of Odorless Thiols and Sulfides and Their Applications to Organic Synthesis
Nishide, Kiyoharu,Ohsugi, Shin-Ichi,Miyamoto, Tetsuo,Kumar, Kamal,Node, Manabu
, p. 189 - 200 (2007/10/03)
Development of new odorless thiols (dodecanethiol, 4-n- heptylphenylmethanethiol, 4-trimethylsilylphenylmethanethiol, 4-trimethylsilylbenzenethiol) and an odorless sulfide (1-methylsulfanyldodecane) and their applications to dealkylation, Michael addition, Swern oxidation, and Corey-Kim oxidation are described.
Synthetic equivalents of benzenethiol and benzyl mercaptan having faint smell: Odor reducing effect of trialkylsilyl group
Nishide, Kiyoharu,Miyamoto, Tetsuo,Kumar, Kamal,Ohsugi, Shin-Ichi,Node, Manabu
, p. 8569 - 8573 (2007/10/03)
Syntheses and odor tests of the trialkylsilylated benzyl mercaptans and benzenethiols have revealed that the trimethylsilyl substituent on the benzene ring has a remarkable effect in reducing the foul smell of the parent benzyl mercaptan and benzenethiol.
