19064-74-5

Basic information

• Product Name: 6-BROMO-PHTHALAZINE
• Synonyms: 6-BROMO-PHTHALAZINE
• CAS NO: 19064-74-5
• Molecular Formula: C₈H₅BrN₂
• Molecular Weight: 209.0427
• Mol File: 19064-74-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 387.3 °C at 760 mmHg
• Flash Point: 188 °C
• Appearance: /
• Density: 1.656 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.21±0.30(Predicted)
• CAS DataBase Reference: 6-BROMO-PHTHALAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-PHTHALAZINE(19064-74-5)
• EPA Substance Registry System: 6-BROMO-PHTHALAZINE(19064-74-5)

Safety Data

• Hazardous Substances Data: 19064-74-5(Hazardous Substances Data)

Usage

Uses

6-Bromophthalazine is a derivative of phthalazine (P382500). Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors.

Upstream product

• 41097-38-5 (1E,2E)-1,2-bis(4-bromobenzylidene)hydrazine 
• 13209-32-0 4-bromophthalaldehyde 
• 1083040-98-5 N-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-N'-[1-(4-bromo-phenyl)-meth-(E)-ylidene]-hydrazine 

Downstream Products

• 1201842-46-7 N-(2-chloro-5-(6-phthalazinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Synthesis method of 6-bromophthalazine

The invention relates to a synthetic method of 6-bromophthalazine. The synthetic method comprises the following steps: 1) taking 4-bromo-1,2-xylene as a raw material, and adopting a free radical reaction to synthesize a compound III; 2) generating a compound IV from the compound III obtained in the step 1) and tert-butyl carbazate under the action of a sodium hydroxide water solution (50%) and a phase transfer catalyst TEAB; 3) generating a compound V from the compound IV obtained in the step 2) under the action of EA/HCl; and 4) generating a compound I from the compound V obtained in the step3) under the action of triethylamine and DDQ. The problems that in the prior art, the intermediates are unstable, and process amplification is difficult are solved. The shortages that the reaction conditions are severe, and the requirements on equipment and operators are very high, and the overall reaction yield is low are overcome. The synthesis method has the advantages of mild reaction conditions, high yield in each step, simple post-treatment, easiness in operation and suitability for process amplification.

USE OF TRIFLUOROMETHYL SUBSTITUTED BENZAMIDES IN THE TREATMENT OF NEUROLOGICAL DISORDERS

The invention relates to methods of using the compounds of the invention, including trifluoromethyl substituted benzamide compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.

PHTHALAZINE DERIVATIVES FROM AROMATIC ALDAZINES

A Lewis acid mediated synthesis of phthalazine derivatives II and III from aromatic aldazines I is reported.