190723-59-2

Upstream product

• 14447-18-8 benzyl 2-cyanoacetate 
• 190723-54-7 1-[(2R,5R)-4-Benzeneselenonyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 190723-42-3 Methanesulfonic acid (2R,3R,4R,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester 
• 190723-52-5 1-[(2R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 58-96-8 uridine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 130351-68-7 1-(5-O-tert-butyldiphenylsilyl-β-D-ribofuranosyl)uracil 
• 130351-69-8 1-<5-O-(tert-butyldiphenylsilyl)-2,3-epoxy-β-D-lyxo-pentofuranosyl>uracil 

Downstream Products

• 190723-60-5 (1R,2S,4R,5S,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-cyano-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-oxa-bicyclo[3.1.0]hexane-6-carboxylic acid 

Relevant academic research and scientific papers

2′,3′-Cyclopropanated Nucleoside Dimers

Syntheses of three novel conformationally rigid dimers containing cyclopropyl -amide and -sulfonamide functionalities are described. Their incorporation into an oligonucleotide sequence resulted in considerable lowering of the Tm's in binding to their complementary RNA sequences.