190778-69-9Relevant academic research and scientific papers
Structure-activity relationships study at the 3'-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3'-(t)-butylaminocarbonyloxy bearing paclitaxel analogs
Chen, Shu-Hui,Xue, May,Huang, Stella,Long, Byron H.,Fairchild, Craig A.,Rose, William C.,Kadow, John F.,Vyas, Dolatrai
, p. 3057 - 3062 (2007/10/03)
An efficient syntheses of the 3'-N isomeric paclitaxel analogs, 4 and 5, are described. A highly diastereoselective Sharpless asymmetric dihydroxylation reaction is utilized to establish the required (2'R,3'S) stereochemistry on the C-13 side chain. Both of the 3'-N modified analogs 4 and 5 were found to be cytotoxic in vitro, Analog 4 also displayed comparable in vivo activity to that of paclitaxel in the ip M-109 tumor model.
