PYR-HIS-PRO-AMC is a synthetic peptide substrate used in biochemical and molecular biology research. It consists of the amino acid sequence pyroglutamyl-histidyl-proline-7-amino-4-methylcoumarin. When cleaved by enzymes such as proteases and peptidases, the AMC fragment is released, producing a fluorescence signal that can be measured to assess enzyme activity. PYR-HIS-PRO-AMC is valuable for studying enzyme kinetics and for drug discovery research in the pharmaceutical industry.
190836-86-3
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Basic information
- Product Name: PYR-HIS-PRO-AMC
- Synonyms: THYROTROPIN-RELEASING HORMONE-AMC;PYR-HIS-PRO-AMC;TRH-AMC
- CAS NO:190836-86-3
- Molecular Formula: C26H28N6O6
- Molecular Weight: 520.54
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: PYR-HIS-PRO-AMC(CAS DataBase Reference)
- NIST Chemistry Reference: PYR-HIS-PRO-AMC(190836-86-3)
- EPA Substance Registry System: PYR-HIS-PRO-AMC(190836-86-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 190836-86-3(Hazardous Substances Data)
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190836-86-3 Usage
Uses
Used in Biochemistry and Molecular Biology Research:PYR-HIS-PRO-AMC is used as a substrate for measuring enzyme activity, particularly for proteases and peptidases. The release of the AMC fragment upon enzyme cleavage generates a fluorescence signal, allowing researchers to assess enzyme activity and study enzyme kinetics.
Used in Pharmaceutical Industry:
PYR-HIS-PRO-AMC is used in drug discovery research to identify and develop potential therapeutic agents that can modulate enzyme activity. By measuring the fluorescence signal generated upon enzyme cleavage, researchers can evaluate the effectiveness of candidate compounds in inhibiting or activating specific enzymes, contributing to the development of new drugs targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 190836-86-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,8,3 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.Calculate Digit Verification of CAS Registry Number 190836-86:
(8*1)+(7*9)+(6*0)+(5*8)+(4*3)+(3*6)+(2*8)+(1*6)=163
163 % 10 = 3
So 190836-86-3 is a valid CAS Registry Number.
190836-86-3Upstream product
190836-86-3Downstream Products
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PYR-HIS-PRO-AMC
