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190904-27-9

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190904-27-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 190904-27-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,9,0 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 190904-27:
(8*1)+(7*9)+(6*0)+(5*9)+(4*0)+(3*4)+(2*2)+(1*7)=139
139 % 10 = 9
So 190904-27-9 is a valid CAS Registry Number.

190904-27-9Downstream Products

190904-27-9Relevant articles and documents

Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics

Adang, Anton E. P.,De Man, Adrianus P. A.,Vogel, Gerard M. T.,Grootenhuis, Peter D. J.,Smit, Martin J.,Peters, Co A. M.,Visser, Arie,Rewinkel, Jos B. M.,Van Dinther, Theo,Lucas, Hans,Kelder, Jan,Van Aelst, Sjoerd,Meuleman, Dick G.,Van Boeckel, Constant A. A.

, p. 4419 - 4432 (2007/10/03)

Despite intense research over the last 10 years, aided by the availability of X-ray structures of enzyme-inhibitor complexes, only very few truly orally active thrombin inhibitors have been found. We conducted a comprehensive study starting with peptide transition state analogues (TSA). Both hydrophobic nonpeptide analogues as well as hydrophilic peptidic analogues were synthesized. The bioavailability in rats and dogs could be drastically altered depending on the overall charge distribution in the molecule. Compound 27, a tripeptide TSA inhibitor of thrombin, showed an oral bioavailability of 32% in rats and 71% in dogs, elimination half-lives being 58 and 108 min, respectively. The thrombin inhibition constant of compound 27 was 1.1 nM, and in an in vivo arterial flow model, the ED50 was 5.4 nmol/kg.min, comparable to known non-TSA inhibitors. A molecular design was found that combines antithrombotic efficiency with oral bioavailability at low dosages.

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