190910-88-4Relevant articles and documents
Practical phase-transfer synthesis of N-(ethoxycarbonyl)phthalimide and its analogues
Siedlecka, Renata,Skarzewski, Jacek
, p. 2081 - 2086 (1997)
Potassium imides are N-acylated with ethyl chloroformate in the presence of tetrabutylammonium chloride to form the corresponding N-etyhoxycarbonyl derivatives, useful agents for N-protection of primary amines.
Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines
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Paragraph A, (2008/06/13)
Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroiso-indoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.