190912-49-3Relevant articles and documents
N-Acetylmuramyl-L-Alanyl-D-Isoglutamine Glycosides: Effect of Glycoside Bond Configuration and Aglycone on Biological Activity
Zemlyakov,Tsikalov,Kalyuzhin,Kur'yanov,Chirva
, p. 286 - 292 (2007/10/03)
Hexyl, octyl, and cyclohexyl β-glycosides and heptyl and cyclohexyl α-glycosides of muramyl dipeptide (MDP) were synthesized. Tests in vitro and in vivo revealed lower immunostimulating activities of MDP α-glycosides in comparison with the corresponding β-glycosides and MDP itself. In the case of alkyl β-glycosides, differences in hydrocarbon chain lengths (C4-C8) and in aglycone (aliphatic chain and aliphatic or aromatic ring) exerted no substantial effect on the immunostimulating activity.
Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil
Iglesias-Guerra, Fernando,Candela, Jose I.,Bautista, Juan,Alcudia, Felipe,Vega-Perez, Jose M.
, p. 71 - 84 (2007/10/03)
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synthesized in good yield by coupling the chlorambucil moiety to positions C-2 or C-3 of the sugar, directly or via a spacer. The starting material was easily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were tested for cytotoxicity, and some of those that presented the best results were studied for inhibition of cell proliferation. Copyright (C) 1999 Elsevier Science Ltd.