190965-03-8Relevant academic research and scientific papers
Copper-Catalyzed Difunctionalization of Terminal Alkynes with Diazo Esters and Amines to Construct β-Enamino Esters
Gao, Bao,Huang, Hanmin
, p. 4075 - 4084 (2016)
An operationally simple and efficient copper-catalyzed three-component tandem reaction of terminal alkynes, diazo compounds and amines to yield β-enamino esters is described. This straightforward protocol takes place rapidly with a wide range of substrates and gives the desired β-enamino esters in good to excellent yields. Preliminary mechanistic studies suggested that the reaction probably proceeds through Cu-catalyzed formal C–H insertion to produce an alkynoate intermediate, which was then trapped by amines to give the β-enamino esters. (Figure presented.).
Process for producing either optically active n-substituted beta-amino acid and optically active n-substituted beta-amino acid ester or optically active n-substituted 2-homopipecolic acid and optically active n-substituted 2-homopipecolic acid ester
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, (2008/06/13)
The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted β-amino acid alkyl ester or N-substituted 2-homopipecolic acid ester represented by the formula (I): wherein Ar, Rsup
