191033-99-5Relevant academic research and scientific papers
Dual NK1 antagonists - Serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives
Ryckmans, Thomas,Berton, Olivier,Grimee, Renee,Kogej, Thierry,Lamberty, Yves,Pasau, Patrick,Talaga, Patrice,Genicot, Christophe
, p. 3195 - 3198 (2007/10/03)
The synthesis, structure-affinity relationship and activity of benzyloxyphenethyl piperazine derivatives combining NK1 antagonism and serotonin reuptake inhibition is described. Compound 7u was shown to be active in animal models of 5-HT reuptake inhibition and central NK1 receptor blockade, and was demonstrated to be orally active in an integrated model sensitive to both mechanisms. This class of compounds potentially represents a new generation of antidepressants.
