191087-23-7

Basic information

• Product Name: 2-(~18~F)fluoro-5-hydroxy-L-tyrosine
• CAS NO: 191087-23-7
• Molecular Formula: C₉H₁₀¹⁸FNO₄
• Molecular Weight: 214.1809
• Mol File: 191087-23-7.mol
• Article Data: 41

Chemical Properties

• Density: 1.553g/cm³
• Refractive Index: 1.629
• CAS DataBase Reference: 2-(~18~F)fluoro-5-hydroxy-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(~18~F)fluoro-5-hydroxy-L-tyrosine(191087-23-7)
• EPA Substance Registry System: 2-(~18~F)fluoro-5-hydroxy-L-tyrosine(191087-23-7)

Safety Data

• Hazardous Substances Data: 191087-23-7(Hazardous Substances Data)

Upstream product

• 63-84-3 dopa 
• 56-40-6 glycine 
• 129841-03-8 3,4-methylenedioxy-6-[18F]flourobenzyl bromide 
• 90473-00-0 <(+)-2-hydroxypipanyl-3-idene>glycine ethyl ester 
• 5796-17-8 D-Dopa 
• 59-92-7 levodopa 
• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 160850-59-9 1-[¹⁸F]fluoro-2-(iodomethyl)-4,5-dimethoxybenzene 
• 491862-95-4 C₂₈H₃₀⁽¹⁸⁾FNO₄ 

Downstream Products

• 92812-82-3 [18F]-L-3,4-dihydroxy-6-fluorophenylalanine 

Relevant articles and documents

Cu-Mediated Radiofluorination of Aryl Pinacolboronate Esters: Alcohols as Solvents with Application to 6-L-[18F]FDOPA Synthesis

Cu-mediated radiofluorination of arylboronic acid pinacol esters (ArylBPin) using Cu(OTf)2(Py)4 complex is a useful approach for the introduction of [18F]fluorine into non-activated arenes and heteroarenes. Owing to the co

One-pot synthesis of high molar activity 6-[18F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor

A one-pot two-step synthesis of 6-[18F]fluoro-l-DOPA ([18F]FDOPA) has been developed involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is fully automated, provides [18F]FDOPA in good

Base/Cryptand/Metal-Free Automated Nucleophilic Radiofluorination of [18F]FDOPA from Iodonium Salts: Importance of Hydrogen Carbonate Counterion

As evidenced by the number of publications and patents published in the last years, the radiosynthesis of 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine ([18F]FDOPA) using the nucleophilic [18F]F- process remains currently a challenge for the radiochemists scientific community even if promising methods for the radiofluorination of electron-rich aromatic structures were recently developed from arylboronate, arylstannane or iodonium salt precursors. In such context, based on the use of an iodonium triflate salt precursor, we optimized a fast and efficient radiofluorination route fully automated and free from any base, cryptand or metal catalyst for the radiosynthesis of [18F]FDOPA. Using this method, this clinically relevant radiotracer was produced in 64 min, 27–38 % RCY d.c. (n = 5), >99 % RCP, >99 % ee., and high Am 170–230 GBq/μmol. In addition, this optimization study clearly highlighted the important role of a triflate-hydrogen carbonate counterion exchange during the radiolabeling process to achieve high fluorine-18 incorporation yields.