191100-14-8Relevant articles and documents
Migratory dynamic kinetic resolution of carbocyclic allylic alcohols
Manzuna Sapu, Chicco,G?rbe, Tams,Lihammar, Richard,B?ckvall, Jan-E.,Deska, Jan
, p. 5952 - 5955 (2014)
A novel migratory dynamic kinetic resolution based on the interplay between an enzyme acylation catalyst and a heterogeneous Bronsted acid as an isomerization/racemization catalyst gives rise to carbocyclic allylic esters with excellent stereoselectivity
Enzyme- and ruthenium-catalyzed dynamic kinetic resolution of functionalized cyclic allylic alcohols
Lihammar, Richard,Millet, Renaud,Baeckvall, Jan-E.
, p. 12114 - 12120 (2014/01/06)
Enantioselective synthesis of functionalized cyclic allylic alcohols via dynamic kinetic resolution has been developed. Cyclopentadienylruthenium catalysts were used for the racemization, and lipase PS-IM or CALB was employed for the resolution. By optimization of the reaction conditions the formation of the enone byproduct was minimized, making it possible to prepare a range of optically active functionalized allylic alcohols in good yields and high ee's.