191105-29-0Relevant academic research and scientific papers
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
Ohkanda, Junko,Strickland, Corey L.,Blaskovich, Michelle A.,Carrico, Dora,Lockman, Jeffrey W.,Vogt, Andreas,Bucher, Cynthia J.,Sun, Jiazhi,Qian, Yimin,Knowles, David,Pusateri, Erin E.,Sebti, Said M.,Hamilton, Andrew D.
, p. 482 - 492 (2006)
A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that of the extended CVIM tetrapeptide,
