191110-58-4Relevant academic research and scientific papers
Tumor imaging compounds
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Page/Page column 8; 11, (2008/06/13)
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in t
Radiolabeled amino acids for tumor imaging with PET: Radiosynthesis and biological evaluation of 2-amino-3-[18F]fluoro-2-methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid
McConathy, Jonathan,Martarello, Laurent,Malveaux, Eugene J.,Camp, Vernon M.,Simpson, Nicholas E.,Simpson, Chiab P.,Bowers, Geoffrey D.,Olson, Jeffrey J.,Goodman, Mark M.
, p. 2240 - 2249 (2007/10/03)
Novel radiopharmaceuticals, including amino acids, that target neoplasms through their altered metabolic states have shown promising results in preclinical and clinical studies. Two fluorinated analogues of α-aminoisobutyric acid, 2-amino-3-fluoro-2-methy
Synthesis of α-amino acids by addition of putative azido radicals to α-methoxy acrylonitriles derived from aldehydes and ketones
Clive, Derrick L. J.,Etkin, Nola
, p. 2459 - 2462 (2007/10/02)
α-Methoxy acrylonitriles, available from aldehydes and ketones, react with sodium azide in the presence of ceric ammonium nitrate to give azido nitrates; from these compounds, α-amino acids are obtained by sequential treatment with sodium acetate in acetic acid and then methanolic potassium carbonate, followed by hydrogenation.
