191152-29-1Relevant academic research and scientific papers
Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron
Hanessian, Stephen,Abad-Grillo, Teresa,McNaughton-Smith, Grant
, p. 6281 - 6294 (2007/10/03)
Several approaches for the stereocontrolled introduction of a 2-propyl group into (4S)-hydroxymethyl-1,4-butyrolactone via cholate chemistry were investigated. A practical synthesis of the (2R)- and (2S)-isomers was developed.
