191166-45-7Relevant academic research and scientific papers
Synthesis of a fragment a derivative of an antibiotic, nosiheptide
Umemura, Kazuyuki,Noda, Hirofumi,Yoshimura, Juji,Konn, Akihito,Yonezawa, Yasuchika,Shin, Chung-Gi
, p. 1391 - 1396 (1998)
Two 4-ethoxycarbonyl thiazoyly groups were introduced into 2- and 5- positions of 3-hydroxypyridine in 8 steps using 5-cyano-3-hydroxypyridine (2) as the starting material. The pyridine derivative obtained in the last step was converted to a fragment. A derivative (21) by stepwise introduction of the 2-substituted 4-thiazolyl group into the 6-position. The total yield for the formation of 21 via 14 steps was 7.6%.
The synthesis of fragment A of an antibiotic, nosiheptide
Umemura, Kazuyuki,Noda, Hirofumi,Yoshimura, Juji,Konn, Akihito,Yonezawa, Yasuchika,Shin, Chung-Gi
, p. 3539 - 3542 (2007/10/03)
Fragment A derivative(13) of nosiheptide, useful for the total synthesis, was obtained by stepwise introduction of the 25-bis{(4ethoxycarbonyl)-2-thiazolyl} groups and 6-{(2-substituted)-4-thiazolyl} group into 3-hydroxy-5-cyanopyridine (3). The total yield was 7.6% via 14 steps.
