191219-80-4

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Basic information

Product Name: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
Synonyms: YM 976;4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE;4-(3-Chloro-phenyl)-1,7-diethyl-1H-pyrido[2,3-d]pyrimidin-2-one
CAS NO:191219-80-4
Molecular Formula: C₁₇H₁₆ClN₃O
Molecular Weight: 313.78
EINECS: N/A
Product Categories: Cyclic Nucleotide related
Mol File: 191219-80-4.mol
Article Data: 1

Chemical Properties

Melting Point: 132.7-134.0 °C(lit.)
Boiling Point: 485.4°Cat760mmHg
Flash Point: 247.4°C
Appearance: pale yellow/solid
Density: 1.27g/cm³
Vapor Pressure: 1.42E-09mmHg at 25°C
Refractive Index: 1.638
Storage Temp.: 2-8°C
Solubility: DMSO: 16 mg/mL
PKA: 2.11±0.20(Predicted)
CAS DataBase Reference: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE(CAS DataBase Reference)
NIST Chemistry Reference: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE(191219-80-4)
EPA Substance Registry System: 4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE(191219-80-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 191219-80-4(Hazardous Substances Data)

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YM 976;191219-80-4
Cas No: 191219-80-4
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10 Metric Ton
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Amadis Chemical Co., Ltd.
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YM 976
Cas No: 191219-80-4
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BOC Sciences
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4-(3-CHLOROPHENYL)-1,7-DIETHYLPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
Cas No: 191219-80-4
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1-100 Metric Ton/Day
ZHEJIANG JIUZHOU CHEM CO.,LTD
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YM 976;4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyriMidin-2(1H)-one
Cas No: 191219-80-4
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Wuxi Morality Chemical Co., Ltd
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4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2-one
Cas No: 191219-80-4
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NovaChemistry
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191219-80-4 Usage

Uses

YM 976 is an inhibitor of PDE4.

Biological Activity

Orally active PDE4 inhibitor (IC 50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.

Check Digit Verification of cas no

The CAS Registry Mumber 191219-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,2,1 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 191219-80:
(8*1)+(7*9)+(6*1)+(5*2)+(4*1)+(3*9)+(2*8)+(1*0)=134
134 % 10 = 4
So 191219-80-4 is a valid CAS Registry Number.

InChI:InChI=1/C17H16ClN3O/c1-3-13-8-9-14-15(11-6-5-7-12(18)10-11)20-17(22)21(4-2)16(14)19-13/h5-10H,3-4H2,1-2H3

191219-80-4 Well-known Company Product Price

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(Code)Product description
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Sigma
(Y4877) YM 976 ≥98% (HPLC)
191219-80-4
Y4877-10MG
2,483.91CNY
Detail

Sigma
(Y4877) YM 976 ≥98% (HPLC)
191219-80-4
Y4877-50MG
9,909.90CNY
Detail

191219-80-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2-one

1.2 Other means of identification

Product number	-
Other names	YM 976

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:191219-80-4 SDS

191219-80-4Upstream product

191219-80-4Downstream Products

191219-80-4Relevant articles and documents

Pyrido[2,3-D]pyrimidine derivatives and pharmaceutical compositions thereof

-

, (2008/06/13)

PCT No. PCT/JP96/03389 Sec. 371 Date Apr. 30, 1998 Sec. 102(e) Date Apr. 30, 1998 PCT Filed Nov. 20, 1996 PCT Pub. No. WO97/19078 PCT Pub. Date May 29, 1997This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a func

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