191220-79-8

Basic information

• Product Name: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-nitrophenyl)-
• CAS NO: 191220-79-8
• Molecular Formula: C13H9ClN2O3
• Molecular Weight: 276.679
• Mol File: 191220-79-8.mol

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-nitrophenyl)-(191220-79-8)
• EPA Substance Registry System: Methanone, (2-chloro-6-methyl-3-pyridinyl)(3-nitrophenyl)-(191220-79-8)

Safety Data

• Hazardous Substances Data: 191220-79-8(Hazardous Substances Data)

Upstream product

• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 191220-78-7 3-benzoyl-2-chloro-6-methylpyridine 

Downstream Products

• 191220-80-1 N-ethyl-6-methyl-3-(3-nitrobenzoyl)pyridin-2-amine 

Relevant articles and documents

Synthetic studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1,8-naphthyridin-2(1H)-one derivatives.

In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1,8-naphthyridin-2(1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure-activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived from human peripheral blood cells and no effect on the other PDE types (1, 2, 3, 5). The inhibition of the tumor necrosis factor-alpha (TNF-alpha) release in vitro and the carrageenan-induced pleurisy in rats were also described.

Pyrido[2,3-D]pyrimidine derivatives and pharmaceutical compositions thereof

PCT No. PCT/JP96/03389 Sec. 371 Date Apr. 30, 1998 Sec. 102(e) Date Apr. 30, 1998 PCT Filed Nov. 20, 1996 PCT Pub. No. WO97/19078 PCT Pub. Date May 29, 1997This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a func