191226-92-3

Upstream product

• 171815-91-1 N,N-dibenzyl phenylalanin ethyl ester 

Downstream Products

• 223727-94-4 (S)-3-dibenzylamine-2-methylidene-4-phenylbutan-1-ol 
• 223727-90-0 (2S,3S)-N,N-dibenzyl-3-bromomethyl-3,4-epoxy-1-phenylbutan-2-amine 

Relevant academic research and scientific papers

Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

Process for producing 3-amino-2-oxo-1-halogenopropane derivatives

Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.