19123-29-6Relevant articles and documents
Microbial Transformation of Manool and (12Z)-Labda-8(17),12,14-triene by Rhodococcus erythropolis JTS-131
Hieda, Tadaharu,Mikami, Yoichi,Obi, Yukiteru
, p. 787 - 794 (2007/10/02)
Rhodococcus erythropolis JTS-131, a cis-abienol and sclareol transformable bacterium, converted manool and accumulated manoyl oxide in the culture broth.In the presence of metabolic inhibitors, 13β-hydroxylabda-8(17),14-dien-18-oic acid and its methylester (a new compound) were accumulated as the transformation products.This strain also transformed (12Z)-labda-8(17),12,14-triene and accumulated (12Z)-labda-8(17),12,14-trien-18-al in the culture broth.In the presence of metabolic inhibitors, two compounds, (12Z)-labda-8(17),12,14-trien-18-ol and 4,18,19-trinor-3,4-seco-5-oxo-(12Z)-labda-8(17),12,14-trien-3-oic acid were accumulated.Based on the experiments on the degradation sequence, transformation pathways for these two labdanes by the bacterium are proposed.