191230-75-8Relevant academic research and scientific papers
Cyclization of 4,5-diamino pyrazole derivatives and their antibacterial activities
Rizk, Hala F.,Ei-Badawi, Mahmoud A.,Ibrahim, Seham A.,Ei-Borai, Mohamed A.
experimental part, p. 1451 - 1459 (2011/10/30)
A convenient synthesis of intermediate 4,5-diamino-3-aryl-1-phenylpyrazoles 4a-4c was reported. The different cyclization reactions were carried out with chalcone, 2-mercaptoacetic acid and p-anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were determined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro. Copyright
A new efficient route to imidazo[4,5-c]pyrazol-5-ones
Vicentini, Chiara B.,Veronese, Augusto C.,Manfrini, Maurizio
, p. 629 - 632 (2007/10/03)
The synthesis of imidazo[4,5-c]pyrazol-5-ones (6) is reported. 5-Amino-4-ethoxycarbonylaminopyrazoles 3a-g when heated at 200°for 2 hours afford 6a-g. In a similar manner imidazo[4,5-c]pyrazol-5-one (6a) is readily obtained from 4-amino-5-ethoxycarbonylaminopyrazole (5a).
