191273-53-7Relevant academic research and scientific papers
Synthesis of various substituted thienoazepinoisoindol-6-ones
Pigeon, Pascal,Decroix, Bernard
, p. 153 - 158 (2007/10/03)
Study of the regioselectivity of addition of Grignard reagents onto imide ester 7 led to the expected phenyl derivative 12.By contrast, the methyl derivative 15 necessitated the use of a Mannich reaction onto the ketone 4.Finally, reaction of diethyl malonate with ketone 4 exhibited a dehydrogenation leading to a conjugate diester 19 and the expected diester 18. - Keywords: thienoazepine; isoinndol-1-one; Mannich reaction; Knoevenagel condensation
