191283-12-2

Upstream product

• 67-62-9 O-Methylhydroxylamin 
• 55515-07-6 (1α,2α,3α)-podophyllotoxin 
• 477-48-5 podophyllotoxone 
• 593-56-6 N-methoxylamine hydrochloride 

Downstream Products

• 155325-18-1 4β-amino-4-deoxy-epipodophyllotoxin 
• 155252-36-1 4α-acetamido-4-deoxypodophyllotoxin 
• 155325-21-6 4α-amino-4-deoxypicropodophyllotoxin 

Relevant academic research and scientific papers

Hemi-synthesis and biological activity of new analogues of podophyllotoxin

Various 4-analogues of podophyllotoxin and epipodophyllotoxin were obtained via the formation of the corresponding 4-keto derivatives. Methyloximation of podophyllotoxone, followed by subsequent catalytic hydrogenation, gave stereoselective access to 4-α-amino-4-deoxypodophyllotoxin and from there, to the corresponding acetamido and formamido derivatives. Base-catalyzed isomerisation of 4-α-amino-4-deoxypodophyllotoxin led to the corresponding picropodophyllin isomer while the 4-β-amino afforded a neopodophyllotoxin-like derivative. On the other hand, oxirane and hydroxymethyl-containing analogues were prepared from podophyllotoxin and 4-epi-4′-demethyl-podophyllotoxin, using a Takai olefination strategy. In the latter series, carboxaldehyde- and carboxylic acid-containing derivatives were also synthesized.

Bioactive isoxazoline and grime derivatives from 7-ketolignans

A new type of cyclolignans with an isoxazoline ring fused to the cyclolignan core has been prepared from 7-ketolignanolides by reaction with hydroxylamine. The corresponding 7-oxime derivatives have also been obtained. The compounds prepared have been evaluated for their cytotoxic activities over four cell lines.