1913-65-1Relevant academic research and scientific papers
Pyridopyrimidines. X. Synthesis of 3-substituted 2-thioxo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones and their S-alkylation under phase transfer conditions
Dave,Patel
, p. 457 - 461 (2007/10/03)
2-Thioxo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones 3 were synthesized by the cyclocondensation of 2-amino-3-carbethoxy-4,6-dimethylpyridine 1 with methyl-N-aryldithiocarbamates 2 and compared with the condensation between 1 and aryl isothiocyanates 4. When a comparative study of N vs S alkylation of ambident 2-thioxo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones 3 was carried out under liquid-liquid and solid-liquid phase transfer conditions using various alkylating agents 5, the S-alkylated products 6 were obtained exclusively and selectively.
Pyridopyrimidines: Part I--Synthesis and Biological Activity of 2-Thiopyridopyrimidin-4(3H)-ones
Dave, C. G.,Shah, P. R.,Desai, V. B.,Srinivasan, S.
, p. 750 - 752 (2007/10/02)
3,5,7-Trisubstituted 2-thiopyridopyrimidin-4(3H)-ones (IV) have been synthesized by condensation of 2-amino-3-carbethoxy-4,6-disubstituted-pyridines (I) with a variety of isothiocyanates (II) followed by cyclization of the resultant thioureas (III).Some of the synthesized N1-substituted-N2--thioureas (III) and IV have been tested for antibacterial and antihistaminic activities.
