191328-25-3Relevant academic research and scientific papers
COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Page/Page column 479, (2017/09/15)
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
Total synthesis of 7,11-cyclobotryococca-5,12,26-triene using an oxidative radical cyclization as a key step
Davies, Justin J.,Krulle, Thomas M.,Burton, Jonathan W.
supporting information; experimental part, p. 2738 - 2741 (2010/09/04)
(Figure presented) An efficient total synthesis of the novel botryococcene-related hydrocarbon 7,11-cyclobotryococca-5,12,26-triene is reported that uses, as a key step, an oxidative radical cyclization of a 4-pentenyl malonate for the synthesis of a [3.3
Constrained amino acids. The synthesis of glutamine mimetics
Sabol, Jeffrey S.,Flynn, Gary A.,Friedrich, Dirk,Huber, Edward W.
, p. 3687 - 3690 (2007/10/03)
The preparation and utility of conformationally constrained homoserines trans-8a and cis-8b as intermediates for the synthesis of constrained glutamine mimetics trans-1a and cis-1b is presented.
