19133-00-7

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one is used as a potential active pharmaceutical ingredient for its possible anti-inflammatory, antitumor, antioxidant, and antimicrobial properties. Its structural features may contribute to the development of new drugs targeting various health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, (2E)-1-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one may be utilized as a bioactive compound in the development of pesticides or other agricultural chemicals. Its potential antimicrobial properties could be harnessed to protect crops from diseases and pests, thereby increasing agricultural productivity.
(Note: The uses listed are speculative based on the general properties of chalcones and would require experimental validation and regulatory approval before being implemented in any industry.)

Upstream product

• 101571-08-8 2,3-dibromo-1-(4-chloro-phenyl)-3-(4-dimethylamino-phenyl)-propan-1-one 
• 99-91-2 para-chloroacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 73910-97-1 4-[2,6-bis(4-chlorophenyl)pyridin-4-yl]-N,N-dimethylbenzenamine 
• 85460-64-6 [(1R,2S,3S)-2-Benzoyl-3-(4-dimethylamino-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 85460-64-6 [(1R,2R,3S)-2-Benzoyl-3-(4-dimethylamino-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 123032-82-6 [(1R,2R)-2-(4-Chloro-benzoyl)-3-(4-dimethylamino-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 123121-58-4 [(1R,2S,3S)-2-(4-Chloro-benzoyl)-3-(4-dimethylamino-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 75573-12-5 {4-[2-(4-Chloro-phenyl)-6-p-tolyl-pyridin-4-yl]-phenyl}-dimethyl-amine 
• 590419-85-5 Pd[ClC₆H₄C(O)CHC(O)C₆H₄N(CH₃)2]2 
• 101571-08-8 2,3-dibromo-1-(4-chloro-phenyl)-3-(4-dimethylamino-phenyl)-propan-1-one 
• 1606142-35-1 4-(4-chlorophenyl)-2-(4-(N,N-dimethylamino)phenyl)-2,3-dihydro-1,5-benzothiazepine 

Relevant academic research and scientific papers

Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies

N-formyl pyrazoline derivatives (3a–3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carri

Characterization of the Fluorescence Properties of 4-Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

Understanding the mechanisms responsible for the various biological activities of chalcones, particularly the direct cellular targets, presents an unmet challenge. Here, we prepared a series of fluorescent chalcone derivatives as chemical probes for their

Novel benzothiazole based sulfonylureas/sulfonylthioureas: Design, synthesis and evaluation of their antidiabetic potential

In the present study, twenty-eight benzothiazole based sulfonylureas/sulfonylthioureas were synthesized and were assessed for their antidiabetic effect in a normoglycemic rat model by the in vivo oral glucose tolerance test (OGTT). All the synthesized com

Monoamine Oxidase Inhibitory Activity: Methyl- versus Chlorochalcone Derivatives

Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors. As a continuation of our ongoing research into the development of reversible human MAO-B (hMAO-B) inhibitors, two series

Synthesis and evaluation of pyrazolines bearing benzothiazole as anti-inflammatory agents

The present study aims at the synthesis of pyrazolines bearing benzothiazole and their evaluation as anti-inflammatory agents. The synthesized compounds were evaluated for their anti-inflammatory potential using carrageenan induced paw edema model. Two co

Synthesis and anti bacterial and anti-ulcer evaluation of new s-mannich bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones

The synthesis of title compounds were accomplished by synthetic sequence shown in Scheme 1. Chalcones on cyclocondensation with thiourea in ethanol and potassium hydroxide under reflux yielded the respective dihydropyramidin-2(1H)- thiones. Each of the di

Microwave assisted synthesis and antibacterial activity of chalcone derivatives

Chalcone derivatives have been synthesized by equimolar reactions between substituted aldehydes and substituted acetophenones in basic medium by using conventional and microwave assisted technique. These compounds are characterized by FTIR and 1H NMR spectra. Before characterization purity of these compounds has been checked by thin-layer chromatography method. These synthesized compounds have been screened for their antibacterial (E. coli, S. aureus) activities in different concentrations. The results showed that the chalcone derivatives are better at inhibiting growth of both types of bacteria (Gram negative and Gram positive) compared to chloramphenicol.

Design, synthesis and evaluation of chalcone derivatives as anti- Inflammatory, antioxidant and antiulcer agents

In the present study, a series of chalcone derivatives were designed based on QSAR analysis. The designed compounds were synthesized by Claisen Schmidt condensation and evaluated for anti-inflammatory, antioxidant and antiulcer activities. The results of

Analgesic and antimicrobial studies of some 2,4-dichloro-5-fluorophenyl containing arylidenetriazolothiadiazines

2,4-Dichloro-5-fluorophenyl containing 7-arylidenetriazolothiadiazines were obtained by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto- 1,2,4-triazole with 2,3-dibromo-1,3-diarylpropan-1-ones, and also by the reaction of 4-amino-3-(2,4

Syntheses of 1,5-benzothiazepines: Part XXIV - Syntheses of 4-(4-chlorophenyl)-2-(4-dimethyl-aminophenyl)-2,5-dihydro-8-substituted-1,5-benz othiazepines

Single step syntheses of 4-(4-chlorophenyl)-2-(4-dimethylaminophenyl)-2,5-dihydro-8-substituted-1,5-benzo thiazepines have been achieved by the reactions of five 5-substituted-2-uminobenzenethiols with 4-dimethyl aminobenzal-4'-chloroacetophenone in ethanol saturated with HCl gas. The structural assignments of the final products are based on the results of elemental analyses, IR, 1H NMR and mass spectral studies.