191348-84-2Relevant academic research and scientific papers
Synthesis and pharmacological activity of some 2,3-diphenylindole derivatives
Ismail, M. M. F.,Shmeiss, N. A. M. M.,El-Diwani, H. I.,Arbid, M. S.
, p. 288 - 292 (2007/10/03)
2,3-Diphenyl-5-methoxyindole-6-carboxaldehyde 2b is reacted with semicarbazide hydrochloride to give the corresponding semicarbazide derivative 3 which is cyclized to the triazole 4. The chalcones 5a and 5b have been prepared from the 5-hydroxy- and 5-methoxyindole derivatives 2a and 2b respectively by treatment with p-aminoacetophenone and these are then cyclized with hydrazine hydrate to 6a and 6b respectively. 5-Chloro-2,3-diphenylindole 7 is converted into the 6-amino derivative 8 by nitration followed by reduction and the amino derivative is then condensed with salicylaldehyde to give the benzoxazepinyl derivative 9. Compound 8 on treatment with acetonitrile, ethyl isothiocyanate and o-chlorophenol yields 10, 11 and 12 respectively. Compounds 1a and 3 are found to be the more potent antiinflammatory compounds compared to indomethacin and 3 and 5b have been found to be more potent than aspirin.
