191352-94-0Relevant academic research and scientific papers
Tandem Suzuki cross-coupling-Heck reactions
Kojima, Akihiko,Honzawa, Shinobu,Boden, Christopher D. J.,Shibasaki, Masakatsu
, p. 3455 - 3458 (1997)
Tandem Suzuki cross-coupling-Heck reactions were realized in satisfactory yields (up to 66%) by using triphenylarsine as a ligand or co-ligand.
Catalytic asymmetric synthesis of halenaquinone and halenaquinol
Kojima,Takemoto,Sodeoka,Shibasaki
, p. 581 - 589 (2007/10/03)
A catalytic asymmetric synthesis of halenaquinone (1) and halenaquinol (2) has been achieved using an asymmetric Heck reaction or a cascade Suzuki cross-coupling and an asymmetric Heck reaction as a key step. This synthesis also features the one-pot construction of a unique pentacyclic ring system from a tricyclic system using palladium chemistry. Moreover, the use of Ph3As as an achiral ligand has been found to enhance both the cascade Suzuki cross-coupling and also the Heck reaction to a synthetically useful extent.
