191398-65-9Relevant academic research and scientific papers
Bis(α-bromo ketones): Versatile Precursors for Novel Bis(s-triazolo[3,4-b][1,3,4]thiadiazines) and Bis(thiazoles)
Ginidi, Ahmed R. S.,Shaaban, Mohamed R.,Farag, Ahmad M.,Elwahy, Ahmed H. M.
, p. 1421 - 1428 (2015/02/19)
A synthesis of novel bis(s-triazolo[3,4-b][1,3,4]thiadiazines) 4, 5, 6 in which the triazolothiadiazine is linked to the benzene core through the thiadiazine ring via phenoxymethyl spacers was reported. First attempt to synthesize 4, 5, 6 by the reaction of the appropriate bis(acetophenones) with 4-amino-3-mercapto-1,2,4-triazole derivatives using an acidified acetic acid method were unsuccessful. On the other hand, reaction of the corresponding bis(α-bromoketones) with 4-amino-3-mercapto-1,2,4-triazole derivatives afforded 4, 5, 6 in good yields. The reaction pathway is assumed to involve S-alkylation to give bis(aminotriazole) intermediates, followed by intramolecular cyclocondensation to give 4, 5, 6. The successful isolation of the corresponding bis(aminotriazole) intermediates provides strong evidence for the proposed mechanism. The novel bis(thiazoles) 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, linked to alkyl or aryl spacers can also be synthesized by reaction of the appropriate bis(bromoacetyl) compounds 12a, 12b, 12c and 14, 15, 16, 17, 18, 19 with the corresponding thioamide derivatives 20, 21, 22.
New multi-1,2,3-selenadiazole aromatic derivatives
Al-Smadi, Mousa,Ratrout, Samer
, p. 1126 - 1134 (2007/10/03)
The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy-acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the corresponding semicarbazones derivatives 4a-d or hydrazones 5a-d. The reaction with selenium dioxide leads to regiospecific ring closure of semicarbazones or hydrazones to give the multi-1,2,3-selenadiazole aromatic derivatives in high yield.
New many fold 1,2,3-selenadiazole aromatic derivatives
Al-Smadi, Mousa,Ratrout, Samer
, p. 887 - 891 (2007/10/03)
The many fold aromatic ketones 2a-d are versatile compounds for the synthesis of the many fold 1,2,3-selenadiazole aromatic derivatives 5a-d. The preparation starts with the reaction between the many fold bromomethylene benzene derivatives 1a-d and 4-hydroxyacetophenone, which are transformed through the reaction with semicarbazide hydrochloride or ethylhydrazine carboxylate into the corresponding semicarbazones derivatives 3a-d or hydrazones 4a-d. The reaction with selenium dioxide leads to regiospecific ring closure of semicarbazones or hydrazones to give the many fold 1,2,3-selenadiazole aromatic derivatives in high yield.
Multiple 1,2,3-Thiadiazoles
Al-Smadi, Mousa,Hanold, Norbert,Meier, Herbert
, p. 605 - 611 (2007/10/03)
A series of compounds 3a-d,i-n with two or three 1,2,3-thiadiazole rings, useful for photocrosslinking processes, was prepared from the di- or triketones 1a-d,i-n via the corresponding hydrazones 2a-d,i-n by applying the Hurd-Mori method. A special synthe
