1914-62-1Relevant academic research and scientific papers
Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase
Casara,Ganzhorn,Philippo,Chanal,Danzin
, p. 393 - 396 (2007/10/03)
Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.
