1914-66-5

Basic information

• Product Name: AKOS B013936
• Synonyms: CHEMBRDG-BB 3013936;ART-CHEM-BB B013936;AKOS B013936;2-(2,4-Dichlorophenoxy)-2-methylpropanoic acid;2-(2,4,-DICHLOROPHENOXY)ISOBUTYRIC ACID (2,4-DPI);2-(2,4-dichlorophenoxy)-2-methyl-propionic acid;2-(2,4-dichlorophenoxy)-2-methylpropanoic acid(SALTDATA: FREE);Propanoic acid, 2-(2,4-dichlorophenoxy)-2-Methyl-
• CAS NO: 1914-66-5
• Molecular Formula: C₁₀H₁₀Cl₂O₃
• Molecular Weight: 249.09
• Mol File: 1914-66-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 353.2°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: AKOS B013936(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS B013936(1914-66-5)
• EPA Substance Registry System: AKOS B013936(1914-66-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1914-66-5(Hazardous Substances Data)

Usage

Uses

2-(2,4-Dichlorophenoxy)-2-methylpropanoic Acid is a compound used to prepare various phenoxy-N-phenylacetamides as potential P-glycoprotein inhibitors and multidrug resistant reversing agents.

InChI:InChI=1/C10H10Cl2O3/c1-10(2,9(13)14)15-8-4-3-6(11)5-7(8)12/h3-5H,1-2H3,(H,13,14)

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 58937-27-2 α-(2,4-dichloro-phenoxy)-isobutyric acid ethyl ester 

Downstream Products

• 1351938-81-2 3-(2-(2,4-dichlorophenoxy)-2-methylpropanamido)-N-(2-(pyridin-4-yl)ethyl)benzamide 
• 1351938-80-1 3-(2-(2,4-dichlorophenoxy)-2-methylpropanamido)-N-(pyridin-4-ylmethyl)benzamide 
• 1351938-79-8 3-(2-(2,4-dichlorophenoxy)-2-methylpropanamido)-N-(furan-2-ylmethyl)benzamide 
• 1351938-78-7 3-[2-(2,4-dichlorophenoxy)-2-methylpropionylamino]benzoic acid methyl ester 
• 1187627-08-2 N-(8-(3-cyanobenzyl)-8-azabicyclo[3.2.1]octan-3-endo-yl)-2-(2,4-dichlorophenoxy)-2-methylpropanamide 
• 1187627-05-9 N-(8-(3-cyanobenzoyl)-8-azabicyclo[3.2.1]octan-3-endo-yl)-2-(2,4-dichlorophenoxy)-2-methylpropanamide 
• 119423-61-9 5'-[2-(2,4-dichlorophenoxy)-2-methylpropionamido]-2',5'-dideoxy-5-ethyluridine 
• 106690-26-0 3-Benzo[1,3]dioxol-5-yl-6-[1-(2,4-dichloro-phenoxy)-1-methyl-ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 58937-27-2 α-(2,4-dichloro-phenoxy)-isobutyric acid ethyl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which plays a critical role in the establishment and dissemination of Pseudomonas aeruginosa infections. We have recently described the discovery and characterization of a series of inhibitors of P. aeruginosa T3SS based on a phenoxyacetamide scaffold. To better characterize the factors involved in potent T3SS inhibition, we have conducted a systematic exploration of this structure, revealing several highly responsive structure-activity relationships indicative of interaction with a specific target. Most of the structural features contributing to potency were additive, and combination of those features produced optimized inhibitors with IC50 values 1 μM.

INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM

Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.