191418-28-7

Upstream product

• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 169137-66-0 (2S,3S)-2-amino-3-((tert-butyldimethylsilyl)oxy)-3-phenylpropan-1-ol 
• 191418-21-0 1-((1'S,2'S)-1'-phenyl-1'-hydroxy-3'-acetoxy-2'-propyl)-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 191418-22-1 1-(3'-phenyl-propen-3'-on-2'-yl)-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 131895-40-4 1-<(1'S,2'S)-1'-phenyl-1',3'-dihydroxy-2'-propyl>-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 132015-07-7 1-<(1'S,2'S)-1'-phenyl-1',3'-dihydroxy-2'-propyl>-3(S)-phthalimido-4(R)-styryl-azetidin-2-one 
• 915975-01-8 2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester 

Relevant academic research and scientific papers

Total Synthesis of (-)-FD-838 and (-)-Cephalimysin A

We completed a nine-step total synthesis of (-)-FD-838 and (-)-cephalimysin A. Our synthesis features a biogenetically guided assembly of the highly oxidized spirocyclic core by Snider-type tandem epoxidations of the chiral substrate derived from an amino

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

From a set of weakly potent lead compounds, using in silico screening and small library synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as inhibitors of the MDM2-p53 interaction. Two of the most potent compounds, 2-benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3- dihydroisoindol-1-one (76; IC50 = 15.9 ± 0.8 μM) and 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2, 3-dihydroisoindol-1-one (79; IC50 = 5.3 ± 0.9 μM), induced p53-dependent gene transcription, in a dose-dependent manner, in the MDM2 amplified, SJSA human sarcoma cell line.

2-amino-1-phenyl-propan-1,3-diol as chiral auxiliary. Application in the synthesis of cis 3-phthalimido-4-styryl-2-azetidinones

3,4-cis3,4-cis-1-N-(1'-phenyl-1',3'-dihydroxy-2'-propyl)-3-phthalimido-4 -styrylazetidinones were obtained in optically pure form by chiral Staudinger reaction. The cis-α/β-ratio could be influenced by the protective groups of the diol moiety. Removal of the chiral auxiliarity could be accomplished by direct oxidation, or by previous double bond formation, thus the 2-amino-1-phenyl-propan-1,3-diol can be regarded to a generally useful chiral auxiliary.