191469-02-0Relevant academic research and scientific papers
Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thichroman and 1,2,3,4-tetrahydroquinolinecarboxlic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
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Page column 32-33, (2010/11/29)
Compounds of the formula wherein the symbols have the meaning defined in the specification have retinoid-like biological activity.
Synthesis and biological activity of retinoic acid receptor-α specific amides
Beard, Richard L.,Duong, Tien T.,Teng, Min,Klein, Elliott S.,Standevan, Andrew M.,Chandraratna, Roshantha A.S.
, p. 3145 - 3148 (2007/10/03)
Retinoids are analogues of all-trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic use of retinoids is limited due to severe toxicity. We report here the design of retinoid receptor-α specific ligands with growth inhibitory activity in breast cancer cell lines, and which do not cause the cutaneous toxicity associated with the currently available nonselective retinoid agonists.
