191470-38-9

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 3128-06-1 5-ketohexanoic acid 

Downstream Products

• 1049705-00-1 (3R,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3-phenyl-6-(phenylselenyl)-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 191470-40-3 (-)-(2'R)-((2R,6R)-2,6-dimethylpiperidin-1-yl)-2'-phenylethanol 
• 191470-39-0 (-)-(3R,5R,8aS)-(5,8a)-dimethyl-3-phenyl-hexahydrooxazolo[3,2-a]pyridine 
• 177981-20-3 (6R)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-methyl-2-piperidone 

Relevant academic research and scientific papers

Water-based conditions for the microscale parallel synthesis of bicyclic lactams

We report efficient miniaturized conditions to prepare arrays of bicyclic lactams for screening. The nature of the solvent is usually an important factor of reactivity. At a small synthesis scale, when automated pipetting devices are required, physical pr

Solvent-free microwave-assisted Meyers' lactamization

Microwave solvent-free conditions developed for Meyers' lactamization, a typical bielectrophile-binucleophile reaction that produces quaternary centers in a stereoselective manner, give access to Meyers' chiral lactams in good yield and high diastereosele

Asymmetric synthesis of (+) and (-) trans-2,6-dimethylpiperidines

(+) aid (-) trans-2,6-dimethylpiperidines 9 have been prepared from diastereomeric lactams 6 and 11, both available from (R)-(-)-phenylglycinol 4. Diastereoselective C-2 alkylation afforded oxazolidines 7 and 12. Reduction of 7 with LiAlH4 or NaBH4 led to trans-2,6-8 with total retention of configuration. When 12 was reduced with NaBH4, trans derivative 13a was isolated as the major isomer. A mechanism is proposed to explain the different results.