191470-38-9

Basic information

• Product Name: (3R,8aS)-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• Synonyms: (3R,8aS)-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• CAS NO: 191470-38-9
• Molecular Weight: 231.294
• Mol File: 191470-38-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R,8aS)-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,8aS)-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(191470-38-9)
• EPA Substance Registry System: (3R,8aS)-8a-methyl-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(191470-38-9)

Safety Data

• Hazardous Substances Data: 191470-38-9(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 3128-06-1 5-ketohexanoic acid 

Downstream Products

• 177981-20-3 (6R)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-methyl-2-piperidone 
• 191470-39-0 (-)-(3R,5R,8aS)-(5,8a)-dimethyl-3-phenyl-hexahydrooxazolo[3,2-a]pyridine 
• 191470-40-3 (-)-(2'R)-((2R,6R)-2,6-dimethylpiperidin-1-yl)-2'-phenylethanol 
• 1049705-00-1 (3R,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3-phenyl-6-(phenylselenyl)-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 

Relevant articles and documents

Water-based conditions for the microscale parallel synthesis of bicyclic lactams

We report efficient miniaturized conditions to prepare arrays of bicyclic lactams for screening. The nature of the solvent is usually an important factor of reactivity. At a small synthesis scale, when automated pipetting devices are required, physical pr

Asymmetric synthesis of (+) and (-) trans-2,6-dimethylpiperidines

(+) aid (-) trans-2,6-dimethylpiperidines 9 have been prepared from diastereomeric lactams 6 and 11, both available from (R)-(-)-phenylglycinol 4. Diastereoselective C-2 alkylation afforded oxazolidines 7 and 12. Reduction of 7 with LiAlH4 or NaBH4 led to trans-2,6-8 with total retention of configuration. When 12 was reduced with NaBH4, trans derivative 13a was isolated as the major isomer. A mechanism is proposed to explain the different results.