191476-08-1Relevant academic research and scientific papers
IDEBENONE COMPOUNDS
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Page/Page column 55, (2021/10/22)
The present application provides idebenone derivatives or analogues useful for treating a disease or disorder in a subject in need thereof. Pharmaceutical compositions comprising the compounds and methods of treating the disease or disorder are also provided.
Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids
Rivière, Solenne,Vielmuth, Christin,Ennenbach, Christiane,Abdelrahman, Aliaa,Lemke, Carina,Gütschow, Michael,Müller, Christa E.,Menche, Dirk
supporting information, p. 1348 - 1363 (2020/06/17)
The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues highly important. Herein, we report the design, synthesis and biological evaluation of four simplified and partially saturated archazolid derivatives. We also reveal important structure-activity relationship data as well as insights into the pharmacophore of these complex polyketides.
Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge
Ishida, Ryosuke,Matsumoto, Hirokazu,Ichii, Sayaka,Kobayashi, Motomasa,Arai, Masayoshi,Kotoku, Naoyuki
, p. 210 - 223 (2019/09/19)
The tumor microenvironment is considered as one of the important targets for anticancer drug discovery. In particular, nutrient deficiency may be observed in tumor microenvironment; biakamides A-D (1-4) isolated from marine sponge Petrosaspongia sp. as gr
Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1
Flynn, Autumn R.,Mays, Suzanne G.,Ortlund, Eric A.,Jui, Nathan T.
supporting information, p. 1051 - 1056 (2018/09/21)
The orphan nuclear receptor Liver Receptor Homologue-1 (LRH-1) is an emerging drug target for metabolic disorders. The most effective known LRH-1 modulators are phospholipids or synthetic hexahydropentalene compounds. While both classes have micromolar ef
Enantioselective intramolecular aldehyde α-alkylation with simple olefins: Direct access to homo-ene products
Comito, Robert J.,Finelli, Fernanda G.,Macmillan, David W. C.
supporting information, p. 9358 - 9361 (2013/07/26)
A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asymmetric strategy toward the production of a wide range of formyl-substituted rings with alkene transposition. Conceptually, this novel mechanism allows direct access to "homo-ene"-type products.
Enantioselective synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol: Advanced intermediates of solandelactone A and B
Kumaraswamy, Gullapalli,Ramakrishna, Gajula,Sridhar, Balasubramanian
supporting information; experimental part, p. 1778 - 1782 (2011/05/05)
A stereocontrolled synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol is accomplished with predictable absolute stereochemistry via organocatalytic and catalytic asymmetric transfer hydrogenation reactions. The salient feature of this protocol is the genesis of chirality through an organocatalytic reaction and utilized for installing a critical bifunctional trans-cyclopropane motif, which is a key segment of every representative member of the oxylipin class of natural products such as solandelactone A and B.
Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM
Lu, Kui,Huang, Mengwei,Xiang, Zheng,Liu, Yongxiang,Chen, Jiahua,Yang, Zhen
, p. 1193 - 1196 (2007/10/03)
A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally divers
20-Hydroxyeicosatetraenoic Acid (20-HETE): Structural Determinants for Renal Vasoconstriction
Yu, Ming,Alonso-Galicia, Magdalena,Sun, Cheng-Wen,Roman, Richard J.,Ono, Naoya,Hirano, Hitomi,Ishimoto, Tsuyoshi,Reddy, Y. Krishna,Katipally, Kishta Reddy,Reddy, Komandla Malla,Gopal, V. Raj,et al.
, p. 2802 - 2822 (2007/10/03)
The effects of natural and synthetic eicosanoids on the diameter of rat interlobular arteries studied in vitro were compared to that of the potent, endogenous vasoconstrictor 20-HETE. Vasoconstrictor activity was optimum for chain lengths of 20 - 22 carbo
Dimethylthiocarbamate (DMTC): An Alcohol Protecting Group
Barma,Bandyopadhyay,Capdevila, Jorge H.,Falck
, p. 4755 - 4757 (2007/10/03)
(Equation Presented) Dimethylthiocarbamates (DMTCs), prepared from the corresponding alcohols using commercial dimethylthiocarbamoyl chloride, are spectrally simple, achiral, and nonpolar. DMTCs are moderately to highly stable to a wide range of reagents and conditions including metal hydrides, hydroboration, ylides, NaOH, HCl, organolithiums, Grignards, DDQ, PCC, Swern, n-Bu4NF, CrCl2, heat, and Lewis acids. They are readily removed by NalO4 or H2O2 in the presence of other common alcohol protecting groups.
A convenient biphasic process for the monosilylation of symmetrical 1,n- primary diols
Yu, Chengzhi,Liu, Bin,Hu, Longqin
, p. 4281 - 4285 (2007/10/03)
A simple and mild biphasic process was developed for the selective protection of one of two chemically equivalent primary hydroxyl groups in 1,n-diols using t-butyldiphenyl silyl chloride in diisopropyl ethyl amine and dimethyl formamide. (C) 2000 Elsevier Science Ltd.
