191479-27-3

Upstream product

• 191479-25-1 3-Benzyloxymethyl-1-[(3aR,4R,6R,6aR)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione 
• 102147-76-2 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylideneuridine 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 191479-28-4 Malonic acid (3aR,4R,6R,6aR)-6-(3-benzyloxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester 

Relevant academic research and scientific papers

A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases

The design and synthesis of several β-1,4-galactosyltransferase inhibitors are reported. Mimics of the pyrophosphate-Mn2+ complex were the focus of the design. Malonic, tartaric, and monosaccharide moieties were used as replacements of the pyrophosphate moiety, and galactose or azasugars with potent galactosidase inhibitory activity were used as the 'donor' component. Compound 6, in which glucose was used as the pyrophosphate-Mn2+ complex mimic and galactose as the 'donor' component, showed the best inhibitory activity towards the transferase with a K(i) of 119.6 μM.