191479-41-1Relevant academic research and scientific papers
An improved method for the addition reactions of 1,3-dichloroacetone with combined organolithium-cerium trichloride reagents
Chen, Same-Ting,Fang, Jim-Min
, p. 927 - 930 (2007/10/03)
Alkyl-, phenyl- and alkynyllithium reagents in combination with anhydrous cerium(III) chloride underwent addition reactions with 1,3-dichloroacetone in a very efficient manner. The addition products are versatile precursors for 2-substituted epichlorohydrins and glycidols. Fluconazole, a potent antifungal agent, was thus synthesized in 67% yield by addition of 1,3-dichloroacetone to 2,4-difluorophenyllithium in the presence of cerium(III) chloride, followed by substitution of the chlorine atoms with 1,2,4-triazole.
