191487-39-5Relevant academic research and scientific papers
Synthesis of (hetaryl)alkylamines from the reactions of 2-aminopyrimidine, 2-aminothiazole, and 2-aminothiazoline with benzyl bromide and xylylene dibromides
Gondi, Sudershan R.,Son, David Y.
, p. 401 - 410 (2008)
Alkylation reactions of 2-aminopyrimidine, 2-aminothiazole, 2-aminothiazoline, and their Cbz-protected derivatives are described. Reactions with benzyl bromide proceed to give monoalkylated products with 2-aminopyrimidine and 2-aminothiazole, but 2-aminot
Fungal and bacterial regioselective hydroxylation of pyrimidine heterocycles
Gotor, Vicente,Quiros, Margarita,Ramon, Liz,Frigola, Jordi,Fernandez, Rosa
, p. 6421 - 6432 (2007/10/03)
The bacterium Rhodococcus erythropolis is employed to hydroxylate the anxiolytic lesopitron, and this bacterium, together with Agrobacterium sp. and the fungus Beauveria bassiana, are used to extend the field of hydroxylation of heteroaromatic compounds to a series of unexplored pyrimidines. Of all the substrates investigated, only the carbamate 11a is regioselectively hydroxylated by B. bassiana at the C-5 position of the pyrimidine ring; in contrast, the bacteria are able to regioselectively oxidize, when free, the C-2 and/or C-4 positions of the pyrimidine moiety of all the substrates 1a - 12a up to a maximum of two oxidations.
