191489-04-0

Basic information

• Product Name: Toluene-4-sulfonic acid 4-[(4-{[4-({4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyl ester
• Synonyms: Toluene-4-sulfonic acid 4-[(4-{[4-({4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyl ester
• CAS NO: 191489-04-0
• Molecular Weight: 1062.42
• Mol File: 191489-04-0.mol

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid 4-[(4-{[4-({4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid 4-[(4-{[4-({4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyl ester(191489-04-0)
• EPA Substance Registry System: Toluene-4-sulfonic acid 4-[(4-{[4-({4-[(4-benzyloxycarbonylamino-butyl)-tert-butoxycarbonyl-amino]-butyl}-tert-butoxycarbonyl-amino)-butyl]-tert-butoxycarbonyl-amino}-butyl)-tert-butoxycarbonyl-amino]-butyl ester(191489-04-0)

Safety Data

• Hazardous Substances Data: 191489-04-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 179186-58-4 (4-Benzyloxycarbonylamino-butyl)-{4-[tert-butoxycarbonyl-(4-{tert-butoxycarbonyl-[4-(4-hydroxy-butylamino)-butyl]-amino}-butyl)-amino]-butyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

A microgonotropen branched decaaza decabutylamine and its DNA and DNA/transcription factor interactions

The central pyrrole of a site-selective DNA minor groove binding tripyrrole peptide 1 has been attached to a branched decaaza decabutylamine via a -(CH2)3-NHCO-(CH2)3- linker to provide the decaaza-microgonotropen (8). The decaaza decabutylamine moiety of 8 was designed to have a much greater affinity to the phosphodiester linkages of the backbone of DNA. Employing Hoechst 33258 (Ht) as a fluorescent titrant, the equilibrium constants for the binding of 8 to the hexadecameric duplex d(GGCGCA3T3GGCGG)/d(CCGCCA3T3GCGCC) and to calf thymus DNA were determined. The log of the product of equilibrium constants (log K(L1)K(L2) for 1:1 and 1:2 complexes formation at A3T3 is 17 (35°C). Results of studies of the inhibition of the binding of several proteins to target DNA are discussed. Binding of the E2F1 transcription factor to its DNA target is 50% inhibited at ~2 nM concentration of 8.