191535-96-3

Upstream product

• 96013-77-3 3-(tert-butyldimethylsilyloxy)benzyl alcohol 
• 191535-98-5 5-((tert-butyldimethylsilyl)oxy)-2-iodobenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 96013-95-5 3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde 

Downstream Products

• 191536-19-3 N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenyl-4-(tert-butyldimethylsilyloxy)phenacylamine 
• 191536-03-5 N-(5-tert-butyldimethylsilyloxy-2-iodobenzyl)-N-methyl-α-phenylphenacylamine 
• 191536-00-2 5-tert-butyldimethylsilyloxy-2-iodo-N-methylbenzylamine 
• 191535-98-5 5-((tert-butyldimethylsilyl)oxy)-2-iodobenzaldehyde 

Relevant academic research and scientific papers

ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

Provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof, wherein A, B, R 1, R 2, m and n are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

Synthesis and biological evaluation of 7-hydroxy-3,4-diphenyl-1,2- dihydroisoquinolines as new 4-hydroxytamoxifen analogues

A phenolic 3,4-diphenyl-1,2-dihydroisoquinoline derivative (4a) as a new 4-hydroxytamoxifen analogue and a related compound (4c) were synthesized from 3,4-diphenyl-1,2,3,4-tetrahydroisoquinolin-4-ols (5a, c), which were prepared by intramolecular Barbier