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Usage

Uses

Used in Pharmaceutical Industry:
2(RS)-4-Methyl-1-(3-Methylpyridin-2-yl)-2-phenylpiperazine is used as an impurity in the production of Mirtazapine (M365000) for the treatment of major depressive disorder. As an impurity, it is essential to monitor and control its presence in the final product to ensure the safety and efficacy of the medication.

Upstream product

• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 5271-27-2 1-methyl-3-phenylpiperazine 

Relevant academic research and scientific papers

Method for preparing mirtazapine impurity K

The invention discloses a method for preparing a mirtazapine impurity K. The method comprises the steps of adopting 2-chloro-3 methyl-5-nitropyridine as a starting raw material to carry out aromatic nucleophilic substitution reaction with 1-methyl-3-phenylpiperazine at high temperature under a catalyst condition, thus synthesizing 4-methyl-1-(3-methyl-5-nitropyridine-2-yl)-2-phenylpiperazine; carrying out reduction reaction to synthesize 5-methyl-6-(4-methyl-2-phenylpiperazine-1-yl)-pyridine-3-amino; carrying out diazo-reaction on the 5-methyl-6-(4-methyl-2-phenylpiperazine-1-yl)-pyridine-3-amino and a sodium nitrite water solution in a hydrochloric acid solution, reducing at low temperature through a hypophosphorous acid water solution, and synthesizing to obtain the high-purity mirtazapine impurity K. According to the scheme of the invention, an impurity comparison product can be quickly, simply, conveniently and efficiently obtained, and the method makes a contribution to strictly controlling the quality of mirtazapine through adopting an external standard method (i.e., an impurity comparison product method).