191597-70-3

Basic information

• Product Name: {(S)-1-[(S)-2-((1R,2S)-1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester
• CAS NO: 191597-70-3
• Molecular Weight: 630.732
• Mol File: 191597-70-3.mol

Chemical Properties

• CAS DataBase Reference: {(S)-1-[(S)-2-((1R,2S)-1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(S)-1-[(S)-2-((1R,2S)-1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester(191597-70-3)
• EPA Substance Registry System: {(S)-1-[(S)-2-((1R,2S)-1-Benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid tert-butyl ester(191597-70-3)

Safety Data

• Hazardous Substances Data: 191597-70-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 23361-28-6 N-(tert-butyloxycarbonyl)-L-valyl-L-proline 
• 764628-83-3 (3S,4R)-4-Amino-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid ethyl ester 
• 191597-68-9 (3S,4R)-4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid ethyl ester 

Relevant articles and documents

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites

Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S' subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin.