191602-36-5Relevant academic research and scientific papers
Spirocyclic NK1 antagonists II: [4.5]-spiroethers
Williams, Brian J.,Cascieri, Margaret A.,Chicchi, Gary G.,Harrison, Timothy,Owens, Andrew P.,Owen, Simon N.,Rupniak, Nadia M.J.,Tattersall, David F.,Williams, Angela,Swain, Christopher J.
, p. 2719 - 2722 (2002)
A series of novel spiroether-based neurokinin-1 (NK1) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
