191602-60-5 Usage
Description
4-(3-Bromo-4-methoxyphenyl)pyridine is a chemical compound characterized by the molecular formula C12H9BrNO. It is a yellow solid and a substituted pyridine derivative, featuring a bromine atom and a methoxy group attached to the phenyl ring. 4-(3-Bromo-4-methoxyphenyl)pyridine is highly reactive and has demonstrated potential biological and pharmacological activities, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and materials science applications. Its versatile reactivity and structural properties have led to its widespread use in the research and development of various organic and medicinal compounds.
Uses
Used in Pharmaceutical Industry:
4-(3-Bromo-4-methoxyphenyl)pyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its high reactivity and potential biological activities. It contributes to the development of new drugs with improved therapeutic properties and efficacy.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(3-Bromo-4-methoxyphenyl)pyridine is utilized as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structural properties and reactivity enable the creation of novel compounds with enhanced performance and selectivity in agricultural applications.
Used in Materials Science:
4-(3-Bromo-4-methoxyphenyl)pyridine is employed in materials science as a component in the development of advanced materials with specific properties. Its reactivity and structural features allow for the synthesis of materials with tailored characteristics, such as improved stability, conductivity, or optical properties, for various applications in fields like electronics, energy, and nanotechnology.
Used in Research and Development:
4-(3-Bromo-4-methoxyphenyl)pyridine is widely used in research and development for the exploration of its potential applications and properties. Its versatile reactivity and structural properties make it an attractive candidate for the synthesis of new organic and medicinal compounds, as well as for studying its biological and pharmacological activities. 4-(3-Bromo-4-methoxyphenyl)pyridine serves as a valuable tool for scientists and researchers in advancing the understanding of chemical reactions and the development of innovative solutions in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 191602-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,6,0 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 191602-60:
(8*1)+(7*9)+(6*1)+(5*6)+(4*0)+(3*2)+(2*6)+(1*0)=125
125 % 10 = 5
So 191602-60-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H10BrNO/c1-15-12-3-2-10(8-11(12)13)9-4-6-14-7-5-9/h2-8H,1H3
191602-60-5Relevant articles and documents
Large-scale Negishi coupling as applied to the synthesis of PDE472, an inhibitor of phosphodiesterase type 4D
Manley, Paul W.,Acemoglu, Murat,Marterer, Wolfgang,Pachinger, Werner
, p. 436 - 445 (2013/09/06)
5-[2-Methoxy-5-(4-pyridinyl)phenyl]-2,1,3-benzoxadiazole (PDE472) is a selective inhibitor of the phosphodiesterase PDE4D isoenzyme, which is a recognised drug target for the treatment of asthma. Different synthetic routes to PDE472 were investigated, and the research synthesis was optimised to prepare a phase I batch on pilot-plant scale with the focus on the elimination or minimization of inherent process risks. An important refinement of the key Negishi aryl-aryl coupling involved preforming the arylpalladium complex, which was then added to the arylzinc intermediate. Residual palladium was removed from PDE472 via crystallization of the hemi-maleate salt, which afforded drug-substance containing 2 ppm Pd.
