19161-27-4Relevant academic research and scientific papers
Denitrogenative hydrofluorination of aromatic aldehyde hydrazones using (difluoroiodo)toluene
Kulkarni, Kaivalya G.,Miokovic, Boris,Sauder, Matthew,Murphy, Graham K.
, p. 9907 - 9911 (2016/10/31)
An operationally simple conversion of aromatic aldehyde hydrazones to monofluoromethylated arenes is reported. The hypervalent iodine reagent TolIF2 serves as an oxidant, converting the hydrazone to the corresponding diazo compounds. The by-product of the oxidation process, HF, is consumed in situ by a denitrogenative hydrofluorination reaction of the diazo group.
Synthesis and biological evaluation of indazole derivatives
Claramunt, Rosa M.,López, Concepción,López, Ana,Pérez-Medina, Carlos,Pérez-Torralba, Marta,Alkorta, Ibon,Elguero, José,Escames, Germaine,Acu?a-Castroviejo, Darío
experimental part, p. 1439 - 1447 (2011/04/24)
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibiti
Transition-Metal-Catalyzed Formation of trans Alkenes via Coupling of Aldehydes
Zhu, Shifa,Liao, Yuanxi,Zhu, Shizheng
, p. 377 - 380 (2007/10/03)
(Equation presented) Rh2(OAc)4 catalyzed the formation of exclusively trans fluorinated alkenes from aldehydes and pentafluorobenzaldehyde tosylhydrazone salts, which were readily prepared from pentafluorobenzaldehyde using the Bamfo
