191656-11-8

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 214416-11-2 N-(5-methoxy-2-nitrobenzoyl)pyrrolidin-2-methanol 

Relevant academic research and scientific papers

Conversion of amines to imines employing Polymer-Supported Sulfoxide (PSS) and Polymer-Supported Perruthenate (PSP): Synthesis of pyrrolo[2,1-c][1,4] benzodiazepines

An efficient method for the oxidation of secondary amines to the corresponding imines has been developed by employing polymer-supported reagents. This protocol has been extended for the generation of a combinatorial library of substituted pyrrolo[2,1-c][1,4]benzodiazepine derivatives and provides a rapid and clean preparation avoiding conventional purification techniques.

Synthesis of pyrrolobenzodiazepines via the PIFA oxidation of amines. Synthesis of 8-deoxy DC-81

PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an efficient four-step synthesis of 8-deoxy DC-81.