191722-80-2

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 191722-78-8 (S)-Benzyloxy-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-acetic acid 
• 191722-77-7 Benzyloxy-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-acetic acid methyl ester 
• 191722-75-5 N-(tert-butyloxycarbonyl)-L-valyl-DL-α-acetoxyglycine methyl ester 
• 71017-98-6 methyl (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoate 

Relevant academic research and scientific papers

Synthesis of optically pure α-hydroxyglycine peptides

Optically pure a-hydroxyglycine peptides can be prepared by enzymatic resolution of DL-α-(benzyloxy)glycine peptide eaters with subtilisin Carlsberg followed by hydrogenolysis of the benzyl protecting group. The DL-α-(benzyloxy)glycine peptide eaters were obtained from the corresponding serine derivatives via lead tetraacetate oxidation and reaction of the resulting electrophilic glycine equivalents with benzyl alcohol.