191734-26-6

Upstream product

• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 191734-32-4 [(2S,4R)-1-Benzyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-2-yl]-[2-(tert-butyl-dimethyl-silanyl)-3-methyl-3H-imidazol-4-yl]-methanol 
• 351529-72-1 (RS)-[(2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxypyrrolidin-2-yl]-(1-methyl-2-phenylthioimidazol-5-yl)methanol 

Downstream Products

• 164162-35-0 (2R,4S)-4-Benzoylsulfanyl-2-(2-carbamoyl-3-methyl-3H-imidazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid allyl ester 
• 164162-29-2 (2R,4R)-1-allyloxycarbonyl-4-benzoylthio-2-[(2-hydroxymethyl-1-methylimidazol-5-yl)methyl]pyrrolidine 
• 156442-06-7 (2R,4S)-1-Allyloxycarbonyl-4-benzoylthio-2-(1-methyl-imidazol-5-ylmethyl)-pyrrolidine 
• 164162-30-5 (2R,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-[(2-ethoxycarbonyl-1-methylimidazol-5-yl)methyl]pyrrolidine 
• 351529-81-2 (2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-[(1-methylimidazol-5-yl)-phenylthiomethyl]pyrrolidine 
• 156442-03-4 (2R,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-[(1-methylimidazol-5-yl)methyl]pyrrolidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems. Part IV. 2-Alkyl substituents containing cationic heteroaromatics linked via a C-C bond

The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents linked via a C-C bond is described. As a result of these studies, we selected FR21818 (1

Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents

A compound of the formula: STR1 in which R1 is carboxy or protected carboxy, R2 is 1-hydroxyethyl, R3 is methyl, R4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lo

Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs

The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex