19178-25-7

Usage

Uses

Used in Medicinal Chemistry:
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) is utilized as a key building block in the synthesis of diverse bioactive molecules. Its incorporation into various chemical structures allows for the development of new compounds with potential therapeutic applications.
Used in Drug Discovery and Development:
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) is employed as a starting material in the design and synthesis of novel pharmaceutical agents. Its unique structure and potential pharmacological properties make it a valuable component in the creation of new drugs with improved efficacy and selectivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) is used as a precursor in the development of new drugs. Its versatile chemical properties enable the synthesis of a wide range of compounds with potential applications in treating various diseases and medical conditions.
Used in Research and Development:
Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) is also used in research and development settings to explore its potential pharmacological properties and therapeutic applications. Studies on Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) can lead to a better understanding of its mechanism of action and pave the way for the development of innovative treatments.

InChI:InChI=1/C7H5N3O/c11-7-5-1-2-8-3-6(5)9-4-10-7/h1-4H,(H,9,10,11)

Upstream product

• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 3473-63-0 formamidine acetic acid 
• 64188-97-2 3-aminopyridine-4-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 
• 77287-34-4 formamide 

Downstream Products

• 51752-67-1 4-chloro-pyrido[3,4-d]pyrimidine 
• 1167545-68-7 4-[(8-methyl-2-phenylquinolin-3-yl)methoxy]pyrido[3,4-d]pyrimidine 

Relevant academic research and scientific papers

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the identification of non-carboxylate inhibitors derived from pyrido[3,4-d]pyrimidin-4(3H)-one. A number of exemplars such as compound 41 possess interesting activity profiles in KDM4C and KDM5C biochemical and target-specific, cellular mechanistic assays.

SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1

In one aspect, the invention relates to 3-benzylquinazolin-4(3H)-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1/s

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives

Fungicidal compositions contain as active ingredient a 4-substituted-pyrido[3,2-d]pyrimidine, -pyrido[4,3-d]pyrimidine, -pyrido[3,4-d]pyrimidine, pyrido[2,3-d]pyrimidine, -pteridine, -pyrimido[4,5-d]pyrimidine, -pyrimido[4,5-c]pyridazine, -pyrimido[5,4-d]